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Scientist, Biomarker Discovery
Casma Therapeutics in Cambridge, Massachusetts
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Date Posted 12/12/2019
Employment Type Fulltime
Application Deadline Open until filled

Reports to: Scientist II, Biomarker Discovery 

Location: Cambridge, MA 

Casma Overview 

Casma Therapeutics is harnessing the natural cellular process of autophagy to open vast new target areas for drug discovery and development that will profoundly impact the lives of patients. Autophagy is a conserved cellular process that contributes to overall organismal health. Inefficient autophagy flux or defects in lysosomal homeostasis are observed in numerous pathologies, e.g., neurodegeneration, metabolic disorders, inflammation, and muscle degeneration. Casma uses several approaches to intervene at strategic points throughout the autophagy-lysosome system to improve the cellular process of clearing out unwanted proteins, organelles and invading pathogens. By boosting autophagy, Casma expects to be able to arrest or reverse the progression of lysosomal storage disorders, muscle disorders, inflammatory disorders and neurodegeneration, among other indications. Casma was launched in 2018 by Third Rock Ventures and is based in Cambridge, Mass. 

The Role 

We are seeking an exceptional analytical chemist to join our biomarker discovery team. The ideal candidate will be a mass spectrometry expert, with strong fundamentals in analytical problem solving and confidence to carry out important tasks with minimal oversight. The candidate will play a key role in LC-MS/MS method development, data acquisition and data interpretation. We are seeking a qualified candidate who will share our excitement about the science, contribute to our culture, and honor our commitment to patients. 



  • Design and implement targeted and unbiased LC-MS/MS assays to discover small molecule biomarkers of target engagement and disease state.

  • Perform all aspects of analytical chemistry project support including sample preparation, instrument tuning and optimization, data analysis and report authorship.

  • Play an integral role in collaborations with external partners and serve as an analytical chemistry expert and collaborator on interdisciplinary project teams.

Requirements + Qualifications 

  • BS, MS, or PhD with 5+ years of experience in metabolomics and quantitative analysis by mass spectrometry

  • BS/MS with 6-10 years of experience

  • PhD with 3-5 years of experience

  • Extensive direct experience with sample preparation, assay development, chromatographic optimization and instrument tuning

  • Experience with diverse mass analysis modalities including MRM and high-resolution methods.

  • Proficiency with metabolomics data analysis software such as XCMS, MultiQuant, Sciex OS or Compound Discoverer

  • Previous experience with Sciex hardware and software is highly desirable but not required

  • Strong interpersonal and collaboration skills

  • Clear and effective verbal and written communication skills

  • A demonstrated ability to think logically and critically

  • Ability to successfully participate in a highly-creative and enthusiastic start-up environment

  • Exemplify a patient-first focus, courage, integrity, drive, and respect for all team members

Company Values + Culture 

Courage to listen, learn, lead, Awesome science, Strength through collaboration, 

Medical breakthroughs for patients, Always do the right thing 

We have created and are sustaining a creative scientific culture where we recognize and reward our "Casmaniacs" for exemplifying our Core Values, and we accelerate our professional growth through coaching, development, and frequent feedback. Our plan of nurturing the fiercest, most talented and diverse Casmaniacs is coming to fruition before our very eyes. 

Casmaniacs are provided competitive salaries, stock options, bonus eligibility, and excellent benefits including health, dental and vision insurance, life insurance, long-term disability, 401(k), unlimited vacation, generous parental leave, commuter reimbursement, professional development, philanthropic opportunities, and most importantly a sense of community. Casma is proud to be one of Boston's 2019 Best Places to Work by the Boston Business Journal. 

Equal Employment Opportunity 

Casma provides equal employment opportunities to all employees and applicants for employment without regard to race, color, national origin, religion, sexual orientation, gender, gender identity or expression, age, veteran status, disability, pregnancy or conditions related to pregnancy, or genetics.

*Please mention to employers when applying for this job*
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