At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs, but few options.

Neurocrine Biosciences is a neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, endocrine and psychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, Parkinson's disease, endometriosis* and uterine fibroids*, as well as clinical programs in multiple therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. *in collaboration with AbbVie

Our dynamic team is seeking a motivated, collaborative, and experienced scientist to support our in vitro biochemical and cell-based assay development, screening, and lead panel characterizations for our antibody discovery programs. The qualified individual will work closely with team members to design, develop and execute assays to deliver robust and high-quality decision-making data. The position requires excellent scientific, technical and laboratory skills, strong organizational and communications skills, and enthusiasm in contributing to a fast-paced organization focused on discoveries of novel and differentiated therapeutic candidates.

_

• Develops and performs biochemical and cell-based assays, including ADCC/ADCP/CDC reporter assays

• Perform antibody cell-binding assays and multicolor FACS analysis of antibody binding and/or cell marker staining

• Measure cytokines, or other analytes, from cell-based assays or plasma/serum samples using immunoassay platforms such as MSD or ELISA

• Prepare and isolate primary cells, such as CD4+ T cells and monocytes, for in vitro assays

• Thaw, maintain and culture cell lines and primary cells for in vitro assays

• Experience with label-free BLI binding studies to investigate competition and off-target binding of lead antibody panels is a plus

• Responsible for data analysis and reporting

• Tracks and documents assay performance

• Continually provides recommendations to improve on process efficiency and research quality

• Other duties as assigned

• BS/BA degree in scientific field and 2+ years of in vitro pharmacology experience; Preferred experience includes: primary cell culture, and related assay development, liquid handling automation and LIMS systems, antibody screening and related in vitro assays OR

• MS/MA degree in scientific field and some relevant industry experience OR

• PhD in biology or related field preferred and some experience with cell culture and cell-based in vitro assays, development and optimization of in vitro biological assays is required Preferred experience includes: primary cell culture, and related assay development, liquid handling automation and LIMS systems, antibody screening and related in vitro assays

• Experience with flow cytometry and ability to independently perform multicolor flow cytometry experiments and data analyses (FlowJo)

• Good knowledge and demonstrated ability working with a variety of laboratory equipment/tools, such as MSD, plate readers, automation. Experience with label-free technologies, such as Octet BLI and/or SPR is a plus

• Working knowledge of primary cell culture, primary cell assays, cell lines, and transient transfections

• Collaborative and highly motivated

• Good knowledge of scientific principles, methods, and techniques

• Ability to work as part of a team

• Strong computer skills and experience with Prism, Excel, Word, etc.

• Good communications, problem-solving, analytical thinking skills

• Detail oriented

• Ability to meet deadlines

• Good project management skills

#LI-OB1

Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.

We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description.